- Sales, Soupy
- Sanders, Harland
- Sanger, Margaret
- Scalia, Antonin
- Schwartz, Julius
- Schwarz, Frederick Augustus Otto
- Sedgwick, Theodore
- Serling, Rod
- Seward, William
- Sherman, James S.
- Sherman, Roger
- Shriver, Eunice Kennedy
- Shriver, Sargent
- Sinclair, Upton
- Slater, Samuel
- Smith, Horace
- Smith, James
- Smithson, James
- Sousa, John Philip
- Southwick, Alfred
- Spaulding, Elbridge Gerry
- Spock, Benjamin
- Standish, Myles
- Stanton, Edwin M.
- Steinway, Henry Englehard
- Stevens, Thaddeus
- Stevenson, Adlai E., I
- Stevenson, Adlai E., II
- Stewart, Potter
- Stockton, Richard
- Stone, Harlan Fiske
- Story, Joseph
- Stowe, Harriet Beecher
- Stratton, Charles "General Tomb Thumb"
- Sullivan, Anne
- Sullivan, Ed
- Sumner, Charles
- Surratt, John
- Surratt, Mary
- Swayne, Noah
- Sweeney, Charles
